Structure of a GRK5-calmodulin complex reveals molecular mechanism of GRK activation and substrate targeting

The phosphorylation of G protein-coupled receptors (GPCRs) by GPCR kinases (GRKs) facilitates arrestin binding and receptor desensitization. While this process can be regulated by Ca(2+)-binding proteins such as calmodulin (CaM) and recoverin, the molecular mechanisms are poorly understood. Here, we...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Komolov, Konstantin E., Sulon, Sarah M., Bhardwaj, Anshul, van Keulen, Siri C., Duc, Nguyen Minh, Laurinavichyute, Daniela K., Lou, Hua Jane, Turk, Benjamin E., Chung, Ka Young, Dror, Ron O., Benovic, Jeffrey L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7855534/
https://ncbi.nlm.nih.gov/pubmed/33321095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.11.026
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