Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe

G protein-coupled receptor (GPCR) kinases (GRKs) are responsible for initiating desensitization of activated GPCRs. GRK5 is potently inhibited by the calcium-sensing protein calmodulin (CaM), which leads to nuclear translocation of GRK5 and promotion of cardiac hypertrophy. Herein, we report the arc...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Beyett, Tyler S., Fraley, Amy E., Labudde, Emily, Patra, Dhabaleswar, Coleman, Ryan C., Eguchi, Akito, Glukhova, Alisa, Chen, Qiuyan, Williams, Robert M., Koch, Walter J., Sherman, David H., Tesmer, John J. G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689901/
https://ncbi.nlm.nih.gov/pubmed/31337679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1818547116
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