Characterizing the effect of background selection on the polygenicity of brain-related traits

BACKGROUND: Genome-wide association studies (GWAS) have demonstrated that psychopathology phenotypes are affected by many risk alleles with small effect (polygenicity). It is unclear how ubiquitously evolutionary pressures influence the genetic architecture of these traits. METHODS: We partitioned S...

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Bibliografiska uppgifter
I publikationen:Genomics
Huvudupphovsmän: Wendt, Frank R, Pathak, Gita A, Overstreet, Cassie, Tylee, Daniel S, Gelernter, Joel, Atkinson, Elizabeth G, Polimanti, Renato
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7855394/
https://ncbi.nlm.nih.gov/pubmed/33278486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygeno.2020.11.032
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