Characterizing the effect of background selection on the polygenicity of brain-related traits

BACKGROUND: Genome-wide association studies (GWAS) have demonstrated that psychopathology phenotypes are affected by many risk alleles with small effect (polygenicity). It is unclear how ubiquitously evolutionary pressures influence the genetic architecture of these traits. METHODS: We partitioned S...

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Publicado en:Genomics
Autores principales: Wendt, Frank R, Pathak, Gita A, Overstreet, Cassie, Tylee, Daniel S, Gelernter, Joel, Atkinson, Elizabeth G, Polimanti, Renato
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7855394/
https://ncbi.nlm.nih.gov/pubmed/33278486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygeno.2020.11.032
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