Characterizing the effect of background selection on the polygenicity of brain-related traits

BACKGROUND: Genome-wide association studies (GWAS) have demonstrated that psychopathology phenotypes are affected by many risk alleles with small effect (polygenicity). It is unclear how ubiquitously evolutionary pressures influence the genetic architecture of these traits. METHODS: We partitioned S...

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Bibliografski detalji
Izdano u:Genomics
Glavni autori: Wendt, Frank R, Pathak, Gita A, Overstreet, Cassie, Tylee, Daniel S, Gelernter, Joel, Atkinson, Elizabeth G, Polimanti, Renato
Format: Artigo
Jezik:Inglês
Izdano: 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7855394/
https://ncbi.nlm.nih.gov/pubmed/33278486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygeno.2020.11.032
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