Characterizing the effect of background selection on the polygenicity of brain-related traits

BACKGROUND: Genome-wide association studies (GWAS) have demonstrated that psychopathology phenotypes are affected by many risk alleles with small effect (polygenicity). It is unclear how ubiquitously evolutionary pressures influence the genetic architecture of these traits. METHODS: We partitioned S...

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Foilsithe in:Genomics
Main Authors: Wendt, Frank R, Pathak, Gita A, Overstreet, Cassie, Tylee, Daniel S, Gelernter, Joel, Atkinson, Elizabeth G, Polimanti, Renato
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2020
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7855394/
https://ncbi.nlm.nih.gov/pubmed/33278486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygeno.2020.11.032
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