An Advanced Apralog with Increased in-vitro and in-vivo Activity toward Gram-negative Pathogens and Reduced ex-vivo Cochleotoxicity.

We describe the convergent synthesis of a 5-O-β-D-ribofuranosyl-based apramycin derivative (apralog) that displays significantly improved antibacterial activity over the parent apramycin against wild-type ESKAPE pathogens. In addition, the new apralog retains excellent antibacterial activity in the...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:ChemMedChem
Main Authors: Sonousi, Amr, Quirke, Jonathan C. K., Waduge, Prabuddha, Janusic, Tanja, Gysin, Marina, Haldimann, Klara, Xu, Shan, Hobbie, Sven N., Sha, Su-Hua, Schacht, Jochen, Chow, Christine S., Vasella, Andrea, Böttger, Erik C., Crich, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7855274/
https://ncbi.nlm.nih.gov/pubmed/33007139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000726
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados