An Advanced Apralog with Increased in-vitro and in-vivo Activity toward Gram-negative Pathogens and Reduced ex-vivo Cochleotoxicity.

Lignende værker

• Apralogs: Apramycin 5-O-Glycosides and Ethers with Improved Antibacterial Activity and Ribosomal Selectivity and Reduced Susceptibility to the Aminoacyltranserferase (3)-IV Resistance Determinant.
  af: Quirke, Jonathan C. K., et al.
  Udgivet: (2019)
• Effects of the 1-N-(4-Amino-2S-hydroxybutyryl) and 6′-N-(2-Hydroxyethyl) Substituents on Ribosomal Selectivity, Cochleotoxicity and Antibacterial Activity in the Sisomicin Class of Aminoglycoside Antibiotics
  af: Sonousi, Amr, et al.
  Udgivet: (2018)
• Predictive Analysis of the Side Chain Conformation of the Higher Carbon Sugars: Application to the Preorganization of the Aminoglycoside Ring 1 Side Chain for Binding to the Bacterial Ribosomal Decoding A Site
  af: Pirrone, Michael G., et al.
  Udgivet: (2020)
• Design, Multigram Synthesis, and in Vitro and in Vivo Evaluation of Propylamycin: A Semisynthetic 4,5-Deoxystreptamine Class Aminoglycoside for the Treatment of Drug-Resistant Enterobacteriaceae and Other Gram-Negative Pathogens
  af: Matsushita, Takahiko, et al.
  Udgivet: (2019)
• Synthesis, ribosomal selectivity, and antibacterial activity of netilmicin 4′-derivatives
  af: Sonousi, Amr, et al.
  Udgivet: (2019)