Yüklüyor......

An Advanced Apralog with Increased in-vitro and in-vivo Activity toward Gram-negative Pathogens and Reduced ex-vivo Cochleotoxicity.

We describe the convergent synthesis of a 5-O-β-D-ribofuranosyl-based apramycin derivative (apralog) that displays significantly improved antibacterial activity over the parent apramycin against wild-type ESKAPE pathogens. In addition, the new apralog retains excellent antibacterial activity in the...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:ChemMedChem
Asıl Yazarlar: Sonousi, Amr, Quirke, Jonathan C. K., Waduge, Prabuddha, Janusic, Tanja, Gysin, Marina, Haldimann, Klara, Xu, Shan, Hobbie, Sven N., Sha, Su-Hua, Schacht, Jochen, Chow, Christine S., Vasella, Andrea, Böttger, Erik C., Crich, David
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7855274/
https://ncbi.nlm.nih.gov/pubmed/33007139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000726
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!