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An Advanced Apralog with Increased in-vitro and in-vivo Activity toward Gram-negative Pathogens and Reduced ex-vivo Cochleotoxicity.

We describe the convergent synthesis of a 5-O-β-D-ribofuranosyl-based apramycin derivative (apralog) that displays significantly improved antibacterial activity over the parent apramycin against wild-type ESKAPE pathogens. In addition, the new apralog retains excellent antibacterial activity in the...

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Veröffentlicht in:ChemMedChem
Hauptverfasser: Sonousi, Amr, Quirke, Jonathan C. K., Waduge, Prabuddha, Janusic, Tanja, Gysin, Marina, Haldimann, Klara, Xu, Shan, Hobbie, Sven N., Sha, Su-Hua, Schacht, Jochen, Chow, Christine S., Vasella, Andrea, Böttger, Erik C., Crich, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7855274/
https://ncbi.nlm.nih.gov/pubmed/33007139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000726
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