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Generation of highly selective monoclonal antibodies inhibiting a recalcitrant protease using decoy designs
Matrix metalloproteinase-12 (MMP-12), also known as macrophage elastase, is a potent inflammatory mediator and therefore an important pharmacological target. Clinical trial failures of broad-spectrum compound MMP inhibitors suggested that specificity is the key for a successful therapy. To provide t...
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| Veröffentlicht in: | Biotechnol Bioeng |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7855242/ https://ncbi.nlm.nih.gov/pubmed/32716053 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.27519 |
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