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Metformin effectively restores the HPA axis function in diet-induced obese rats
INTRODUCTION: The hypothalamo-pituitary-adrenal (HPA) axis is perturbed in obesity. We previously reported presence of leptin resistance in the brainstem and uncoupling between central noradrenergic tone and the HPA axis in obesity-prone (DIO) rats. Metformin is shown to lower body weight and adipos...
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| Publicado no: | Int J Obes (Lond) |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7855162/ https://ncbi.nlm.nih.gov/pubmed/32951009 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41366-020-00688-z |
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