Responsiveness of hypothalamo-pituitary-adrenal axis to leptin is impaired in diet-induced obese rats

BACKGROUND/OBJECTIVES: Diet-induced obese (DIO) rats have altered stress (HPA) axis activity compared to diet-resistant (DR) rats when chronically exposed to a high-fat (HF) diet. Since stress axis is tightly regulated by leptin, an adipocyte-secreted hormone that is important for controlling body w...

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Vydáno v:Nutr Diabetes
Hlavní autoři: Shin, Andrew C., MohanKumar, Sheba M. J., Balasubramanian, Priya, Sirivelu, Madhu P., Linning, Katrina, Woolcock, Andrew, James, Michelle, MohanKumar, Puliyur S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6423225/
https://ncbi.nlm.nih.gov/pubmed/30886140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41387-019-0076-y
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