YY1 Interacts with Guanine Quadruplexes to Regulate DNA Looping and Gene Expression

The DNA guanine quadruplexes (G4) play important roles in multiple cellular processes, including DNA replication, transcription and maintenance of genome stability. Here, we showed that Yin Yang-1 (YY1) can bind directly to G4 structures. ChIP-Seq results revealed that YY1 binding sites overlap exte...

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Veröffentlicht in:Nat Chem Biol
Hauptverfasser: Li, Lin, Williams, Preston, Ren, Wendan, Wang, Michelle Y., Gao, Zi, Miao, Weili, Huang, Ming, Song, Jikui, Wang, Yinsheng
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7854983/
https://ncbi.nlm.nih.gov/pubmed/33199912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-00695-1
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