Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors

The pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continues to expand. Papain-like protease (PLpro) is one of two SARS-CoV-2 proteases potentially targetable with antivirals. PLpro is an attractive target because it plays an essential role in cleavage and maturation...

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Vydáno v:Nat Commun
Hlavní autoři: Osipiuk, Jerzy, Azizi, Saara-Anne, Dvorkin, Steve, Endres, Michael, Jedrzejczak, Robert, Jones, Krysten A., Kang, Soowon, Kathayat, Rahul S., Kim, Youngchang, Lisnyak, Vladislav G., Maki, Samantha L., Nicolaescu, Vlad, Taylor, Cooper A., Tesar, Christine, Zhang, Yu-An, Zhou, Zhiyao, Randall, Glenn, Michalska, Karolina, Snyder, Scott A., Dickinson, Bryan C., Joachimiak, Andrzej
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7854729/
https://ncbi.nlm.nih.gov/pubmed/33531496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21060-3
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