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Iron derived from autophagy-mediated ferritin degradation induces cardiomyocyte death and heart failure in mice
Heart failure is a major public health problem, and abnormal iron metabolism is common in patients with heart failure. Although iron is necessary for metabolic homeostasis, it induces a programmed necrosis. Iron release from ferritin storage is through nuclear receptor coactivator 4 (NCOA4)-mediated...
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| Pubblicato in: | eLife |
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| Autori principali: | , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications, Ltd
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7853718/ https://ncbi.nlm.nih.gov/pubmed/33526170 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.62174 |
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