TNF-α Regulates Human Plasmacytoid Dendritic Cells by Suppressing IFN-α Production and Enhancing T Cell Activation

Human plasmacytoid dendritic cells (pDCs) play a vital role in modulating immune responses. They can produce massive amounts of type I IFNs in response to nucleic acids via TLRs, but they are also known to possess weak Ag-presenting properties inducing CD4(+) T cell activation. Previous studies show...

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Detalles Bibliográficos
Publicado en:J Immunol
Main Authors: Psarras, Antonios, Antanaviciute, Agne, Alase, Adewonuola, Carr, Ian, Wittmann, Miriam, Emery, Paul, Tsokos, George C., Vital, Edward M.
Formato: Artigo
Idioma:Inglês
Publicado: AAI 2021
Assuntos:
Innate Immunity and Inflammation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7851743/
https://ncbi.nlm.nih.gov/pubmed/33441439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1901358
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