The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer

BACKGROUND: Intrinsic and acquired drug resistance represent fundamental barriers to the cure of high-grade serous ovarian carcinoma (HGSC), the most common histological subtype accounting for the majority of ovarian cancer deaths. Defects in homologous recombination (HR) DNA repair are key determin...

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Publicado no:Br J Cancer
Main Authors: Yan, Shunfei, Xuan, Jiachen, Brajanovski, Natalie, Tancock, Madeleine R. C., Madhamshettiwar, Piyush B., Simpson, Kaylene J., Ellis, Sarah, Kang, Jian, Cullinane, Carleen, Sheppard, Karen E., Hannan, Katherine M., Hannan, Ross D., Sanij, Elaine, Pearson, Richard B., Chan, Keefe T.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7851142/
https://ncbi.nlm.nih.gov/pubmed/33173151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-020-01158-z
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