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CX-5461 can destabilize replication forks in PARP inhibitor-resistant models of ovarian cancer
Acquired drug resistance leads to poor clinical outcome in high grade serous ovarian cancer (HGSOC). We have demonstrated the efficacy of the novel drug CX-5461 in HGSOC is mediated through destabilization of DNA replication forks. The data highlights the potential of CX-5461 in overcoming a general...
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| Publicado no: | Mol Cell Oncol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7671053/ https://ncbi.nlm.nih.gov/pubmed/33235908 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2020.1805256 |
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