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Topoisomerase I prevents transcription-replication conflicts at transcription termination sites
R-loops have both positive and negative impacts on chromosome functions. To identify toxic R-loops, we mapped RNA:DNA hybrids, markers of replication fork stalling and DNA double-strand breaks along the human genome. This analysis indicates that transient replication fork pausing occurs at the trans...
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| izdano v: | Mol Cell Oncol |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Taylor & Francis
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7849740/ https://ncbi.nlm.nih.gov/pubmed/33553603 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2020.1843951 |
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