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Heat activates the AAA+ HslUV protease by melting an axial autoinhibitory plug
At low temperatures, protein degradation by the AAA+ HslUV protease is very slow. New crystal structures reveal that residues in the intermediate domain of the HslU(6) unfoldase can plug its axial channel, blocking productive substrate binding and subsequent unfolding, translocation, and degradation...
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| Udgivet i: | Cell Rep |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7849044/ https://ncbi.nlm.nih.gov/pubmed/33472065 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108639 |
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