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Asymmetric nucleotide transactions of the HslUV protease

ATP binding and hydrolysis are critical for protein degradation by HslUV, a AAA+ machine containing one or two HslU(6) ATPases and the HslV(12) peptidase. Although each HslU homohexamer has six potential ATP-binding sites, we show that only three or four ATP molecules bind at saturation and present...

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Autori principali: Yakamavich, Joseph A., Baker, Tania A., Sauer, Robert T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2517146/
https://ncbi.nlm.nih.gov/pubmed/18582897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.05.070
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