Evaluation of Linezolid Pharmacokinetics in Critically Ill Obese Patients with Severe Skin and Soft Tissue Infections

Linezolid standard dosing is fixed at 600 mg every 12 h (q12h) for adults. Literature suggests critically ill, obese patients require higher doses. The study aim is 2-fold: (i) to describe linezolid pharmacokinetics (PK), and (ii) to evaluate if PK/pharmacodynamic (PD) target attainment is achieved...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Blackman, Alison L., Jarugula, Praneeth, Nicolau, David P., Chui, Sai Ho, Joshi, Manjari, Heil, Emily L., Gopalakrishnan, Mathangi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2021
Assuntos:
Clinical Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7848975/
https://ncbi.nlm.nih.gov/pubmed/33257446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01619-20
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