Runx1 and Runx3 drive progenitor to T-lineage transcriptome conversion in mouse T cell commitment via dynamic genomic site switching

Runt domain-related (Runx) transcription factors are essential for early T cell development in mice from uncommitted to committed stages. Single and double Runx knockouts via Cas9 show that target genes responding to Runx activity are not solely controlled by the dominant factor, Runx1. Instead, Run...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Shin, Boyoung, Hosokawa, Hiroyuki, Romero-Wolf, Maile, Zhou, Wen, Masuhara, Kaori, Tobin, Victoria R., Levanon, Ditsa, Groner, Yoram, Rothenberg, Ellen V.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7848575/
https://ncbi.nlm.nih.gov/pubmed/33479171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2019655118
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