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Stage-specific action of Runx1 and GATA3 controls silencing of PU.1 expression in mouse pro–T cells
PU.1 (encoded by Spi1), an ETS-family transcription factor with many hematopoietic roles, is highly expressed in the earliest intrathymic T cell progenitors but must be down-regulated during T lineage commitment. The transcription factors Runx1 and GATA3 have been implicated in this Spi1 repression,...
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| Pubblicato in: | J Exp Med |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Rockefeller University Press
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8241539/ https://ncbi.nlm.nih.gov/pubmed/34180951 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20202648 |
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