Stage-specific action of Runx1 and GATA3 controls silencing of PU.1 expression in mouse pro–T cells

PU.1 (encoded by Spi1), an ETS-family transcription factor with many hematopoietic roles, is highly expressed in the earliest intrathymic T cell progenitors but must be down-regulated during T lineage commitment. The transcription factors Runx1 and GATA3 have been implicated in this Spi1 repression,...

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Bibliographic Details
Published in:J Exp Med
Main Authors: Hosokawa, Hiroyuki, Koizumi, Maria, Masuhara, Kaori, Romero-Wolf, Maile, Tanaka, Tomoaki, Nakayama, Toshinori, Rothenberg, Ellen V.
Format: Artigo
Language:Inglês
Published: Rockefeller University Press 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8241539/
https://ncbi.nlm.nih.gov/pubmed/34180951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20202648
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