Pathogenic role of delta 2 tubulin in bortezomib-induced peripheral neuropathy

The pathogenesis of chemotherapy-induced peripheral neuropathy (CIPN) is poorly understood. Here, we report that the CIPN-causing drug bortezomib (Bort) promotes delta 2 tubulin (D2) accumulation while affecting microtubule stability and dynamics in sensory neurons in vitro and in vivo and that the...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Pero, Maria Elena, Meregalli, Cristina, Qu, Xiaoyi, Shin, Grace Ji-eun, Kumar, Atul, Shorey, Matthew, Rolls, Melissa M., Tanji, Kurenai, Brannagan, Thomas H., Alberti, Paola, Fumagalli, Giulia, Monza, Laura, Grueber, Wesley B., Cavaletti, Guido, Bartolini, Francesca
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7848563/
https://ncbi.nlm.nih.gov/pubmed/33468672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2012685118
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