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Metabolite Profiling of Dihydroartemisinin in Blood of Plasmodium-Infected and Healthy Mice Using UPLC-Q-TOF-MS(E)

Dihydroartemisinin (DHA) and its’ derivatives have been employed as the most powerful first-line drugs for malarial treatment for several decades. The metabolism of DHA has not been studied clearly. Previous reports were focused on the pharmacokinetics procedure of DHA in healthy rats. The metabolit...

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Bibliografische gegevens
Gepubliceerd in:Front Pharmacol
Hoofdauteurs: Zhao, Yifan, Sun, Peng, Ma, Yue, Chang, Xiaoqiang, Chen, Xingyu, Ji, Xin, Bai, Yue, Zhang, Dong, Yang, Lan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2021
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7848114/
https://ncbi.nlm.nih.gov/pubmed/33536920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.614159
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