Balanced Wnt/Dickkopf-1 signaling by mesenchymal vascular progenitor cells in the microvascular niche maintains distal lung structure and function

The well-described Wnt inhibitor Dickkopf-1 (DKK1) plays a role in angiogenesis as well as in regulation of growth factor signaling cascades in pulmonary remodeling associated with chronic lung diseases (CLDs) including emphysema and fibrosis. However, the specific mechanisms by which DKK1 influence...

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Udgivet i:Am J Physiol Cell Physiol
Main Authors: Summers, Megan E., Richmond, Bradley W., Kropski, Jonathan A., Majka, Sarah A., Bastarache, Julie A., Hatzopoulos, Antonis K., Bylund, Jeffery, Ghosh, Moumita, Petrache, Irina, Foronjy, Robert F., Geraghty, Patrick, Majka, Susan M.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7846975/
https://ncbi.nlm.nih.gov/pubmed/33085496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00277.2020
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