Balanced Wnt/Dickkopf-1 signaling by mesenchymal vascular progenitor cells in the microvascular niche maintains distal lung structure and function

The well-described Wnt inhibitor Dickkopf-1 (DKK1) plays a role in angiogenesis as well as in regulation of growth factor signaling cascades in pulmonary remodeling associated with chronic lung diseases (CLDs) including emphysema and fibrosis. However, the specific mechanisms by which DKK1 influence...

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Detalhes bibliográficos
Publicado no:Am J Physiol Cell Physiol
Main Authors: Summers, Megan E., Richmond, Bradley W., Kropski, Jonathan A., Majka, Sarah A., Bastarache, Julie A., Hatzopoulos, Antonis K., Bylund, Jeffery, Ghosh, Moumita, Petrache, Irina, Foronjy, Robert F., Geraghty, Patrick, Majka, Susan M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7846975/
https://ncbi.nlm.nih.gov/pubmed/33085496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00277.2020
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