Balanced Wnt/Dickkopf-1 signaling by mesenchymal vascular progenitor cells in the microvascular niche maintains distal lung structure and function

The well-described Wnt inhibitor Dickkopf-1 (DKK1) plays a role in angiogenesis as well as in regulation of growth factor signaling cascades in pulmonary remodeling associated with chronic lung diseases (CLDs) including emphysema and fibrosis. However, the specific mechanisms by which DKK1 influence...

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Veröffentlicht in:Am J Physiol Cell Physiol
Hauptverfasser: Summers, Megan E., Richmond, Bradley W., Kropski, Jonathan A., Majka, Sarah A., Bastarache, Julie A., Hatzopoulos, Antonis K., Bylund, Jeffery, Ghosh, Moumita, Petrache, Irina, Foronjy, Robert F., Geraghty, Patrick, Majka, Susan M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2021
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7846975/
https://ncbi.nlm.nih.gov/pubmed/33085496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00277.2020
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