The level of oncogenic Ras determines the malignant transformation of Lkb1 mutant tissue in vivo

The genetic and metabolic heterogeneity of RAS-driven cancers has confounded therapeutic strategies in the clinic. To address this, rapid and genetically tractable animal models are needed that recapitulate the heterogeneity of RAS-driven cancers in vivo. Here, we generate a Drosophila melanogaster...

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Vydáno v:Commun Biol
Hlavní autoři: Rackley, Briana, Seong, Chang-Soo, Kiely, Evan, Parker, Rebecca E., Rupji, Manali, Dwivedi, Bhakti, Heddleston, John M., Giang, William, Anthony, Neil, Chew, Teng-Leong, Gilbert-Ross, Melissa
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7846793/
https://ncbi.nlm.nih.gov/pubmed/33514834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-01663-8
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