Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics

Infiltrative growth is a major cause of high lethality of malignant brain tumors such as glioblastoma (GBM). We show here that GBM cells upregulate guidance receptor Plexin-B2 to gain invasiveness. Deletion of Plexin-B2 in GBM stem cells limited tumor spread and shifted invasion paths from axon fibe...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Commun Biol
Prif Awduron: Huang, Yong, Tejero, Rut, Lee, Vivian K., Brusco, Concetta, Hannah, Theodore, Bertucci, Taylor B., Junqueira Alves, Chrystian, Katsyv, Igor, Kluge, Michael, Foty, Ramsey, Zhang, Bin, Friedel, Caroline C., Dai, Guohao, Zou, Hongyan, Friedel, Roland H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2021
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7846610/
https://ncbi.nlm.nih.gov/pubmed/33514835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-01667-4
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