Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics

Infiltrative growth is a major cause of high lethality of malignant brain tumors such as glioblastoma (GBM). We show here that GBM cells upregulate guidance receptor Plexin-B2 to gain invasiveness. Deletion of Plexin-B2 in GBM stem cells limited tumor spread and shifted invasion paths from axon fibe...

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發表在:Commun Biol
Main Authors: Huang, Yong, Tejero, Rut, Lee, Vivian K., Brusco, Concetta, Hannah, Theodore, Bertucci, Taylor B., Junqueira Alves, Chrystian, Katsyv, Igor, Kluge, Michael, Foty, Ramsey, Zhang, Bin, Friedel, Caroline C., Dai, Guohao, Zou, Hongyan, Friedel, Roland H.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2021
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7846610/
https://ncbi.nlm.nih.gov/pubmed/33514835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-01667-4
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