Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics

Infiltrative growth is a major cause of high lethality of malignant brain tumors such as glioblastoma (GBM). We show here that GBM cells upregulate guidance receptor Plexin-B2 to gain invasiveness. Deletion of Plexin-B2 in GBM stem cells limited tumor spread and shifted invasion paths from axon fibe...

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Publicat a:Commun Biol
Autors principals: Huang, Yong, Tejero, Rut, Lee, Vivian K., Brusco, Concetta, Hannah, Theodore, Bertucci, Taylor B., Junqueira Alves, Chrystian, Katsyv, Igor, Kluge, Michael, Foty, Ramsey, Zhang, Bin, Friedel, Caroline C., Dai, Guohao, Zou, Hongyan, Friedel, Roland H.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7846610/
https://ncbi.nlm.nih.gov/pubmed/33514835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-01667-4
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