Nalaganje...
DNA ligase I variants fail in the ligation of mutagenic repair intermediates with mismatches and oxidative DNA damage
DNA ligase I (LIG1) joins DNA strand breaks during DNA replication and repair transactions and contributes to genome integrity. The mutations (P529L, E566K, R641L and R771W) in LIG1 gene are described in patients with LIG1-deficiency syndrome that exhibit immunodeficiency. LIG1 senses 3’-DNA ends wi...
Shranjeno v:
| izdano v: | Mutagenesis |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7846189/ https://ncbi.nlm.nih.gov/pubmed/32914844 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/mutage/geaa023 |
| Oznake: |
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