The anti-tumour activity of DNA methylation inhibitor 5-aza-2′-deoxycytidine is enhanced by the common analgesic paracetamol through induction of oxidative stress

The DNA demethylating agent 5-aza-2′-deoxycytidine (DAC, decitabine) has anti-cancer therapeutic potential, but its clinical efficacy is hindered by DNA damage-related side effects and its use in solid tumours is debated. Here we describe how paracetamol augments the effects of DAC on cancer cell pr...

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Veröffentlicht in:Cancer Lett
Hauptverfasser: Gleneadie, Hannah J., Baker, Amy H., Batis, Nikolaos, Bryant, Jennifer, Jiang, Yao, Clokie, Samuel J.H., Mehanna, Hisham, Garcia, Paloma, Gendoo, Deena M.A., Roberts, Sally, Burley, Megan, Molinolo, Alfredo A., Gutkind, J. Silvio, Scheven, Ben A., Cooper, Paul R., Parish, Joanna L., Khanim, Farhat L., Wiench, Malgorzata
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier Science Ireland 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7845757/
https://ncbi.nlm.nih.gov/pubmed/33359448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2020.12.029
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