Phenotypic and Genotypic Adaptations in Pseudomonas aeruginosa Biofilms following Long-Term Exposure to an Alginate Oligomer Therapy

Chronic Pseudomonas aeruginosa lung infections in cystic fibrosis (CF) evolve to generate environmentally adapted biofilm communities, leading to increased patient morbidity and mortality. OligoG CF-5/20, a low-molecular-weight inhaled alginate oligomer therapy, is currently in phase IIb/III clinica...

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Bibliografiska uppgifter
I publikationen:mSphere
Huvudupphovsmän: Oakley, Juliette L., Weiser, Rebecca, Powell, Lydia C., Forton, Julian, Mahenthiralingam, Eshwar, Rye, Philip D., Hill, Katja E., Thomas, David W., Pritchard, Manon F.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2021
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7845618/
https://ncbi.nlm.nih.gov/pubmed/33472983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.01216-20
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