A Low-Molecular-Weight Alginate Oligosaccharide Disrupts Pseudomonal Microcolony Formation and Enhances Antibiotic Effectiveness

In chronic respiratory disease, the formation of dense, 3-dimensional “microcolonies” by Pseudomonas aeruginosa within the airway plays an important role in contributing to resistance to treatment. An in vitro biofilm model of pseudomonal microcolony formation using artificial-sputum (AS) medium was...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Pritchard, Manon F., Powell, Lydia C., Jack, Alison A., Powell, Kate, Beck, Konrad, Florance, Hannah, Forton, Julian, Rye, Philip D., Dessen, Arne, Hill, Katja E., Thomas, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5571347/
https://ncbi.nlm.nih.gov/pubmed/28630204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00762-17
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