A comprehensive enhancer screen identifies TRAM2 as a key and novel mediator of YAP oncogenesis

BACKGROUND: Frequent activation of the co-transcriptional factor YAP is observed in a large number of solid tumors. Activated YAP associates with enhancer loci via TEAD4-DNA-binding protein and stimulates cancer aggressiveness. Although thousands of YAP/TEAD4 binding-sites are annotated, their funct...

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Foilsithe in:Genome Biol
Main Authors: Li, Li, Ugalde, Alejandro P., Scheele, Colinda L. G. J., Dieter, Sebastian M., Nagel, Remco, Ma, Jin, Pataskar, Abhijeet, Korkmaz, Gozde, Elkon, Ran, Chien, Miao-Ping, You, Li, Su, Pin-Rui, Bleijerveld, Onno B., Altelaar, Maarten, Momchev, Lyubomir, Manber, Zohar, Han, Ruiqi, van Breugel, Pieter C., Lopes, Rui, ten Dijke, Peter, van Rheenen, Jacco, Agami, Reuven
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2021
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7845134/
https://ncbi.nlm.nih.gov/pubmed/33514403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-021-02272-8
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