Tumor-intrinsic and -extrinsic determinants of response to blinatumomab in adults with B-ALL

Blinatumomab, a bispecific antibody that directs CD3(+) T cells to CD19(+) tumor cells, shows variable efficacy in B-progenitor acute lymphoblastic leukemia (B-ALL). To determine tumor-intrinsic and -extrinsic determinants of response, we studied 44 adults with relapsed or refractory B-ALL (includin...

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發表在:Blood
Main Authors: Zhao, Yaqi, Aldoss, Ibrahim, Qu, Chunxu, Crawford, Jeremy Chase, Gu, Zhaohui, Allen, Emma K., Zamora, Anthony E., Alexander, Thomas B., Wang, Jeremy, Goto, Hiroaki, Imamura, Toshihiko, Akahane, Koshi, Marcucci, Guido, Stein, Anthony S., Bhatia, Ravi, Thomas, Paul G., Forman, Stephen J., Mullighan, Charles G., Roberts, Kathryn G.
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2021
主題:
Clinical Trials and Observations
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7845009/
https://ncbi.nlm.nih.gov/pubmed/32881995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020006287
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