iPSC-derived cardiomyocytes from patients with myotonic dystrophy type 1 have abnormal ion channel functions and slower conduction velocities

Cardiac complications such as electrical abnormalities including conduction delays and arrhythmias are the main cause of death in individuals with Myotonic Dystrophy type 1 (DM1). We developed a disease model using iPSC-derived cardiomyocytes (iPSC-CMs) from a healthy individual and two DM1 patients...

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Vydáno v:Sci Rep
Hlavní autoři: Poulin, Hugo, Mercier, Aurélie, Djemai, Mohammed, Pouliot, Valérie, Deschenes, Isabelle, Boutjdir, Mohamed, Puymirat, Jack, Chahine, Mohamed
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7844414/
https://ncbi.nlm.nih.gov/pubmed/33510259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-82007-8
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