HLA-DRB1 allelic epitopes that associate with autoimmune disease risk or protection activate reciprocal macrophage polarization

Associations between particular human leukocyte antigen (HLA) alleles and susceptibility to—or protection from—autoimmune diseases have been long observed. Allele-specific antigen presentation (AP) has been widely proposed as a culprit, but it is unclear whether HLA molecules might also have non-AP,...

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Veröffentlicht in:Sci Rep
Hauptverfasser: van Drongelen, Vincent, Scavuzzi, Bruna Miglioranza, Nogueira, Sarah Veloso, Miller, Frederick W., Sawalha, Amr H., Holoshitz, Joseph
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7844024/
https://ncbi.nlm.nih.gov/pubmed/33510427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-82195-3
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