Shared epitope–aryl hydrocarbon receptor crosstalk underlies the mechanism of gene–environment interaction in autoimmune arthritis

The susceptibility to autoimmune diseases is affected by genetic and environmental factors. In rheumatoid arthritis (RA), the shared epitope (SE), a five-amino acid sequence motif encoded by RA-associated HLA-DRB1 alleles, is the single most significant genetic risk factor. The risk conferred by the...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Fu, Jiaqi, Nogueira, Sarah V., van Drongelen, Vincent, Coit, Patrick, Ling, Song, Rosloniec, Edward F., Sawalha, Amr H., Holoshitz, Joseph
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2018
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5939100/
https://ncbi.nlm.nih.gov/pubmed/29666259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1722124115
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