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Proliferative polyploid cells give rise to tumors via ploidy reduction

Polyploidy is a hallmark of cancer, and closely related to chromosomal instability involved in cancer progression. Importantly, polyploid cells also exist in some normal tissues. Polyploid hepatocytes proliferate and dynamically reduce their ploidy during liver regeneration. This raises the question...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Nat Commun
Hauptverfasser: Matsumoto, Tomonori, Wakefield, Leslie, Peters, Alexander, Peto, Myron, Spellman, Paul, Grompe, Markus
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7843634/
https://ncbi.nlm.nih.gov/pubmed/33510149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-20916-y
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