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Proliferative polyploid cells give rise to tumors via ploidy reduction
Polyploidy is a hallmark of cancer, and closely related to chromosomal instability involved in cancer progression. Importantly, polyploid cells also exist in some normal tissues. Polyploid hepatocytes proliferate and dynamically reduce their ploidy during liver regeneration. This raises the question...
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| Udgivet i: | Nat Commun |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7843634/ https://ncbi.nlm.nih.gov/pubmed/33510149 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-20916-y |
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