Neutrophil-to-hepatocyte communication via LDLR-dependent miR-223–enriched extracellular vesicle transfer ameliorates nonalcoholic steatohepatitis

Neutrophil infiltration around lipotoxic hepatocytes is a hallmark of nonalcoholic steatohepatitis (NASH); however, how these 2 types of cells communicate remains obscure. We have previously demonstrated that neutrophil-specific microRNA-223 (miR-223) is elevated in hepatocytes to limit NASH progres...

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Dettagli Bibliografici
Pubblicato in:J Clin Invest
Autori principali: He, Yong, Rodrigues, Robim M., Wang, Xiaolin, Seo, Wonhyo, Ma, Jing, Hwang, Seonghwan, Fu, Yaojie, Trojnár, Eszter, Mátyás, Csaba, Zhao, Suxian, Ren, Ruixue, Feng, Dechun, Pacher, Pal, Kunos, George, Gao, Bin
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7843220/
https://ncbi.nlm.nih.gov/pubmed/33301423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI141513
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