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The Two Cysteines of Tau Protein Are Functionally Distinct and Contribute Differentially to Its Pathogenicity in Vivo

Although Tau accumulation is clearly linked to pathogenesis in Alzheimer's disease and other Tauopathies, the mechanism that initiates the aggregation of this highly soluble protein in vivo remains largely unanswered. Interestingly, in vitro Tau can be induced to form fibrillar filaments by oxi...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Prifti, Engie, Tsakiri, Eleni N., Vourkou, Ergina, Stamatakis, George, Samiotaki, Martina, Papanikolopoulou, Katerina
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7842753/
https://ncbi.nlm.nih.gov/pubmed/33334867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1920-20.2020
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