Inhibition of mitochondrial carrier homolog 2 (MTCH2) suppresses tumor invasion and enhances sensitivity to temozolomide in malignant glioma

BACKGROUND: Malignant glioma exerts a metabolic shift from oxidative phosphorylation (OXPHOs) to aerobic glycolysis, with suppressed mitochondrial functions. This phenomenon offers a proliferation advantage to tumor cells and decrease mitochondria-dependent cell death. However, the underlying mechan...

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Publicado en:Mol Med
Autores principales: Yuan, Qiuyun, Yang, Wanchun, Zhang, Shuxin, Li, Tengfei, Zuo, Mingrong, Zhou, Xingwang, Li, Junhong, Li, Mao, Xia, Xiaoqiang, Chen, Mina, Liu, Yanhui
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7842075/
https://ncbi.nlm.nih.gov/pubmed/33509092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s10020-020-00261-4
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