Notch signaling drives synovial fibroblast identity and arthritis pathology

The synovium is a mesenchymal tissue composed mainly of fibroblasts with a lining and sublining that surrounds the joints. In rheumatoid arthritis (RA), the synovial tissue undergoes marked hyperplasia, becomes inflamed and invasive and destroys the joint(1,2). Recently, we and others found that a s...

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Udgivet i:Nature
Main Authors: Wei, Kevin, Korsunsky, Ilya, Marshall, Jennifer L., Gao, Anqi, Watts, Gerald F. M., Major, Triin, Croft, Adam P., Watts, Jordan, Blazar, Philip, Lange, Jeffrey, Thornhill, Thomas, Filer, Andrew, Raza, Karim, Donlin, Laura T., Siebel, Christian W., Buckley, Christopher D., Raychaudhuri, Soumya, Brenner, Michael B.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7841716/
https://ncbi.nlm.nih.gov/pubmed/32499639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2222-z
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