Notch signaling drives synovial fibroblast identity and arthritis pathology

The synovium is a mesenchymal tissue composed mainly of fibroblasts with a lining and sublining that surrounds the joints. In rheumatoid arthritis (RA), the synovial tissue undergoes marked hyperplasia, becomes inflamed and invasive and destroys the joint(1,2). Recently, we and others found that a s...

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Vydáno v:Nature
Hlavní autoři: Wei, Kevin, Korsunsky, Ilya, Marshall, Jennifer L., Gao, Anqi, Watts, Gerald F. M., Major, Triin, Croft, Adam P., Watts, Jordan, Blazar, Philip, Lange, Jeffrey, Thornhill, Thomas, Filer, Andrew, Raza, Karim, Donlin, Laura T., Siebel, Christian W., Buckley, Christopher D., Raychaudhuri, Soumya, Brenner, Michael B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7841716/
https://ncbi.nlm.nih.gov/pubmed/32499639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2222-z
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