Salicylic diamines selectively eliminate residual undifferentiated cells from pluripotent stem cell-derived cardiomyocyte preparations

Clinical translation of pluripotent stem cell (PSC) derivatives is hindered by the tumorigenic risk from residual undifferentiated cells. Here, we identified salicylic diamines as potent agents exhibiting toxicity to murine and human PSCs but not to cardiomyocytes (CMs) derived from them. Half maxim...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Burkert, Karsten, Taheri, Hadiseh, Hamad, Sarkawt, Oliverio, Matteo, Peinkofer, Gabriel, Kornfeld, Jan-Wilhelm, Harnying, Wacharee, Pfannkuche, Kurt, Hescheler, Jürgen, Berkessel, Albrecht, Šarić, Tomo
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7841182/
https://ncbi.nlm.nih.gov/pubmed/33504837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-81351-z
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