Salicylic diamines selectively eliminate residual undifferentiated cells from pluripotent stem cell-derived cardiomyocyte preparations

Clinical translation of pluripotent stem cell (PSC) derivatives is hindered by the tumorigenic risk from residual undifferentiated cells. Here, we identified salicylic diamines as potent agents exhibiting toxicity to murine and human PSCs but not to cardiomyocytes (CMs) derived from them. Half maxim...

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Foilsithe in:Sci Rep
Main Authors: Burkert, Karsten, Taheri, Hadiseh, Hamad, Sarkawt, Oliverio, Matteo, Peinkofer, Gabriel, Kornfeld, Jan-Wilhelm, Harnying, Wacharee, Pfannkuche, Kurt, Hescheler, Jürgen, Berkessel, Albrecht, Šarić, Tomo
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2021
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7841182/
https://ncbi.nlm.nih.gov/pubmed/33504837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-81351-z
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