BRD4 inhibition sensitizes aggressive non-Hodgkin lymphomas to PI3Kδ inhibitors by suppressing PI3K reactivation and c-MYC expression

Targeting phosphatidylinositol 3-kinase δ (PI3Kδ) is an important therapeutic strategy for indolent non-Hodgkin lymphomas (NHLs). However, we previously observed reactivation of phosphatidylinositol 3-kinase (PI3K) pathways in aggressive NHL cell lines following continuous exposure to PI3Kδ inhibito...

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Publicado en:Am J Cancer Res
Autores principales: Zuo, Weiqiong, Zhu, Yongxia, Liu, Zhihao, Xia, Yong, Xu, Ying, Peng, Cuiting, Yu, Luoting, Wang, Ningyu
Formato: Artigo
Lenguaje:Inglês
Publicado: e-Century Publishing Corporation 2021
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7840716/
https://ncbi.nlm.nih.gov/pubmed/33520370
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