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Active and Inactive Cdc42 Differ in Their Insert Region Conformational Dynamics

Cell division control protein 42 homolog (Cdc42) protein, a Ras superfamily GTPase, regulates cellular activities, including cancer progression. Using all-atom molecular dynamics (MD) simulations and essential dynamic analysis, we investigated the structure and dynamics of the catalytic domains of G...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biophys J
Prif Awduron: Haspel, Nurit, Jang, Hyunbum, Nussinov, Ruth
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Biophysical Society 2021
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7840443/
https://ncbi.nlm.nih.gov/pubmed/33347888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.12.007
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