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Enantioselective Total Synthesis of (−)‐Finerenone Using Asymmetric Transfer Hydrogenation
(−)‐Finerenone is a nonsteroidal mineralocorticoid receptor antagonist currently in phase III clinical trials for the treatment of chronic kidney disease in type 2 diabetes. It contains an unusual dihydronaphthyridine core. We report a 6‐step synthesis of (−)‐finerenone, which features an enantiosel...
Shranjeno v:
| izdano v: | Angew Chem Int Ed Engl |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
John Wiley and Sons Inc.
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7839499/ https://ncbi.nlm.nih.gov/pubmed/32890415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202011256 |
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