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Asymmetric Nazarov Cyclizations of Unactivated Dienones by Hydrogen-Bond-Donor/Lewis Acid Co-Catalyzed, Enantioselective Proton-Transfer

We report an enantioselective Nazarov cyclization catalyzed by chiral hydrogen-bond-donors in concert with silyl Lewis acids. The developed transformation provides access to tri-substituted cyclopentenones in high levels of enantioselectivity (up to 95% e.e.) from a variety of simple unactivated die...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Adv Synth Catal
Hauptverfasser: Metternich, Jan B., Reiterer, Martin, Jacobsen, Eric N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7643875/
https://ncbi.nlm.nih.gov/pubmed/33162875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adsc.202000831
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